In perimenopause, FSH levels rise, predicting menopause and correlating with symptoms and chronic disease risk
These nutraceuticals likely act through multiple pathways as antioxidants reducing cellular stress in clock-regulating tissues, as ligands for clock-modulating receptors, and by influencing sirtuins and other clock-linked metabolic sensors (Ghi et al., 2021
Administration route significantly impacts optimal dosing frequency
To mitigate this drawback, the pharmacological administration of GIP, primarily known for its insulinotropic and mild appetite-suppressing properties [7], is also suggested to have an anti-emetic effect, potentially allowing GIP co-agonism to increase tolerability to the GLP-1 component [8]
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